Ratiometric MRI sensors based on core-shell nanoparticles for quantitative pH imaging

Satoshi Okada, Shin Mizukami, Takao Sakata, Yutaka Matsumura, Yoshichika Yoshioka, Kazuya Kikuchi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Ratiometric MRI sensors consist of paramagnetic cores and pH-sensitive polymer shells. The core-shell nanostructure enables the coexistence of two incompatible NMR relaxation properties in one particle. The sensors show pH sensitivity in transverse relaxivity (r2), but not in longitudinal relaxivity (r1). Quantitative pH imaging is achieved by measuring the r2/r1 value with a clinical 3 T MRI scanner.

Original languageEnglish
Pages (from-to)2989-2992
Number of pages4
JournalAdvanced Materials
Issue number19
Publication statusPublished - 2014 May 21
Externally publishedYes


  • contrast agents
  • core-shell nanoparticles
  • magnetic resonance imaging
  • pH-responsive polymers
  • ratiometric sensors

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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