Ratchet model of motor proteins and its energetics

Yohei Nakayama, Eiro Muneyuki

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We describe the energetics of motor proteins by taking F1 -ATPase as an example. To clarify the meaning of the mechanical works which are experimentally measured, we first identify the heat, which satisfies the second law of thermodynamics, and next formulate the work through the first law of thermodynamics. The theoretical expressions of the mechanical works reveal that the experimentally measured works have a theoretical basis. Contrary to the mechanical work, the measurement of the heat is still developing. We introduce an attempt to measure a part of the heat, which is related to the experimentally accessible quantities through a nonequilibrium equality.

Original languageEnglish
Title of host publicationThe Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery
PublisherSpringer Singapore
Pages231-243
Number of pages13
ISBN (Electronic)9789811084591
ISBN (Print)9789811084584
DOIs
Publication statusPublished - 2018 May 7
Externally publishedYes

Keywords

  • First and second laws of thermodynamics
  • Motor protein
  • Nonequilibrium system
  • Single-molecule experiment

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Nakayama, Y., & Muneyuki, E. (2018). Ratchet model of motor proteins and its energetics. In The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery (pp. 231-243). Springer Singapore. https://doi.org/10.1007/978-981-10-8459-1_14