Rare genotype of his/his in NUDT15 codon 139 and thiopurine-associated adverse events in a case of ulcerative colitis

Kei Tomiyoshi, Hiroki Sato, Kentaro Tominaga, Yuzo Kawata, Daisuke Okamoto, Yoichi Kakuta, Junji Yokoyama, Shuji Terai

Research output: Contribution to journalArticle

Abstract

Thiopurine drugs are commonly used to treat immunologic diseases. However, the narrow therapeutic safety margin demands evidence-based precision medicine approaches. NUDT15 variants are associated with thiopurine-induced adverse events, particularly in Asians. We herein report a rare genotype of His/His in NUDT15 codon 139 in a case of ulcerative colitis and review the relevant literature. The patient experienced severe thiopurine-associated adverse events, including leukopenia and alopecia. There is no literature on the His/His genotype in NUDT15 codon 139, and our case suggests cautious use or the contraindication of thiopurines for patients with this genotype.

Original languageEnglish
Pages (from-to)1611-1613
Number of pages3
JournalInternal Medicine
Volume59
Issue number13
DOIs
Publication statusPublished - 2020 Jul 1

Keywords

  • His/His genotype
  • Inflammatory bowel disease
  • Leukopenia
  • NUDT15
  • Thiopurine
  • Ulcerative colitis

ASJC Scopus subject areas

  • Internal Medicine

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