Positron emission tomography (PET) with [18F]-FDG can display cancerous activity depending on glucose uptake. Consequently, different PET tracers with different metabolisms are needed for further indication. We have developed multifunctional PET agents by combining 62Zn2+ ion with laserphyrin- and bisglycosylated 5,10,15,20-tetrakis(pentafluorophenyl) porphyrins (H2Glccis-2 and H2Glctrans-2), which can be easily synthesized and have a half-life of 9h. 62Zn-Labeled chemicals were successfully detected as PET signals in vivo and showed PDT-induced cell death by photoirradiation.
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