Rapid synthesis of 62Zn-Labeled S-Glycosylated porphyrin as positron emission tomography tracers for in vivo PET imaging

Masato Tamura, Hirofumi Matsui, Shiho Hirohara, Kiyomi Kakiuchi, Masao Tanihara, Naruto Takahashi, Kozi Nakai, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Positron emission tomography (PET) with [18F]-FDG can display cancerous activity depending on glucose uptake. Consequently, different PET tracers with different metabolisms are needed for further indication. We have developed multifunctional PET agents by combining 62Zn2+ ion with laserphyrin- and bisglycosylated 5,10,15,20-tetrakis(pentafluorophenyl) porphyrins (H2Glccis-2 and H2Glctrans-2), which can be easily synthesized and have a half-life of 9h. 62Zn-Labeled chemicals were successfully detected as PET signals in vivo and showed PDT-induced cell death by photoirradiation.

Original languageEnglish
Pages (from-to)778-780
Number of pages3
JournalChemistry Letters
Volume43
Issue number6
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Rapid synthesis of <sup>62</sup>Zn-Labeled S-Glycosylated porphyrin as positron emission tomography tracers for in vivo PET imaging'. Together they form a unique fingerprint.

  • Cite this

    Tamura, M., Matsui, H., Hirohara, S., Kakiuchi, K., Tanihara, M., Takahashi, N., Nakai, K., Kanai, Y., Watabe, H., & Hatazawa, J. (2014). Rapid synthesis of 62Zn-Labeled S-Glycosylated porphyrin as positron emission tomography tracers for in vivo PET imaging. Chemistry Letters, 43(6), 778-780. https://doi.org/10.1246/cl.140056