Rapid growth of dermatofibrosarcoma protuberans associated with bilateral adrenalectomy for Cushing's syndrome

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Abstract

We describe a 50-year-old Japanese patient with dermatofibrosarcoma protuberans (DFSP) rapidly growing after bilateral adrenalectomy for Cushing's syndrome that reduced the serum level of cortisol from 17.1 to 0.8 mg/dl. It is known that glucocorticoids decrease the transcriptions of the COL1A1 gene and the PDGFB gene, which is under the direct control of the COL1A1 gene in most DFSP. Therefore, the hypersecretion of glucocorticoids in Cushing's syndrome might suppress the development of DFSP. To the best of our knowledge, this is the first case of rapid growth of DFSP that may be associated with bilateral adrenalectomy for Cushing's syndrome.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalCase Reports in Dermatology
Volume3
Issue number2
DOIs
Publication statusPublished - 2011 May

Keywords

  • Bilateral adrenalectomy
  • COL1A1/PDGFB fusion gene
  • Cushing's syndrome
  • Dermatofibrosarcoma protuberans

ASJC Scopus subject areas

  • Dermatology

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