TY - JOUR
T1 - Rapid and Progressive CD4+ Decline in a Monkey Infected with an SIV/HIV-1 Chimeric Virus
AU - Nagamachi, Daiji
AU - Igarashi, Tatsuhiko
AU - Shimada, Toshihide
AU - Kuwata, Takeo
AU - Ui, Masahiro
AU - Ami, Yasushi
AU - Enose, Yoshimi
AU - Ido, Eiji
AU - Fukumoto, Manabu
AU - Hayami, Masanori
PY - 1998/3
Y1 - 1998/3
N2 - We previously constructed a simian immunodeficiency virus/human immunodeficiency virus type 1 (HIV-1) chtmeric virus, NM-3rN to generate a pathogenic HIV-1 in macaque monkeys. During the in vivo passage of this virus in several monkeys, a viral strain, R43-56 was obtained which acquired a better replication ability in vivo. MM121, one of the three monkeys inoculated with the R43-56, showed weight loss, diarrhea and a rapid and continuous decrease in CD4+ lymphocytes at the moribund stage. An autopsy revealed generalized lymphadenopathy, dehydration, and ileocecal intussusception. In situ hybridization showed that the virus infection was in systemic lymphoid organs. We are presently monitoring the survivors to obtain candidates for a more virulent virus. R43-56 may be a better challenge virus and useful tool for human acquired immunodeficiency syndrome research.
AB - We previously constructed a simian immunodeficiency virus/human immunodeficiency virus type 1 (HIV-1) chtmeric virus, NM-3rN to generate a pathogenic HIV-1 in macaque monkeys. During the in vivo passage of this virus in several monkeys, a viral strain, R43-56 was obtained which acquired a better replication ability in vivo. MM121, one of the three monkeys inoculated with the R43-56, showed weight loss, diarrhea and a rapid and continuous decrease in CD4+ lymphocytes at the moribund stage. An autopsy revealed generalized lymphadenopathy, dehydration, and ileocecal intussusception. In situ hybridization showed that the virus infection was in systemic lymphoid organs. We are presently monitoring the survivors to obtain candidates for a more virulent virus. R43-56 may be a better challenge virus and useful tool for human acquired immunodeficiency syndrome research.
KW - Challenge virus
KW - HIV-1 vaccine development
KW - SIV/HIV-1 chimeric virus
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U2 - 10.1292/jvms.60.361
DO - 10.1292/jvms.60.361
M3 - Article
C2 - 9560787
AN - SCOPUS:0032019567
VL - 60
SP - 361
EP - 363
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
SN - 0916-7250
IS - 3
ER -