Rapamycin protects against early brain injury independent of cerebral blood flow changes in a mouse model of subarachnoid haemorrhage

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2 Citations (Scopus)

Abstract

We evaluated the neuroprotective role of rapamycin, a mammalian target of rapamycin (mTOR) kinase inhibitor, in cerebral ischaemia and locomotor function in a mouse model of subarachnoid haemorrhage (SAH). Pretreatment with rapamycin, an mTOR kinase inhibitor, resulted in better recovery from cerebral hypoxia early after SAH than control (P <.05), while the values of peak flow velocity in the middle cerebral artery did not change significantly (P >.05). Average distance travelled and the ratio of central-area distance/total travelled distance determined by open-field test after day 14 was significantly higher in mice pretreated with rapamycin than in control mice (P <.05). Inhibition of the mTOR pathway could be protective against post-SAH early brain injury, ameliorating brain tissue hypoxia and locomotor hypoactivity.

Original languageEnglish
Pages (from-to)859-862
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume45
Issue number8
DOIs
Publication statusPublished - 2018 Aug

Keywords

  • cerebral blood flow
  • early brain injury
  • mammalian target of rapamycin
  • mouse model
  • subarachnoid haemorrhage

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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