Randomized controlled trial on effectiveness of ultrasonography screening for breast cancer in women aged 40-49 (J-START): Research design

Noriaki Ohuchi, Takanori Ishida, Masaaki Kawai, Yoko Narikawa, Seiichiro Yamamoto, Tomotaka Sobue

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In cancer screening, it is essential to undertake effective screening with appropriate methodology, which should be supported by evidence of a reduced mortality rate. At present, mammography is the only method for breast cancer screening with such evidence. However, mammography does not achieve sufficient accuracy in breasts with high density at ages below 50. Although ultrasonography achieves better accuracy in Breast Cancer detection even in dense breasts, the effectiveness has not been verified. We have planned a randomized controlled trial to assess the effectiveness of ultrasonography in women aged 40-49, with a design to study 50 000 women with mammography and ultrasonography (intervention group), and 50 000 controls with mammography only (control group). The participants are scheduled to take second round screening with the same modality 2 years on. The primary endpoints are sensitivity and specificity, and the secondary endpoint is the rate of advanced breast cancers.

Original languageEnglish
Pages (from-to)275-277
Number of pages3
JournalJapanese journal of clinical oncology
Volume41
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1

Keywords

  • Breast cancer screening
  • Mammography
  • Randomized controlled trial
  • Ultrasonography

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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