Raman spectroscopic analysis of H2O2-stimulated three-dimensional human skin models containing Asian, black, and Caucasian Melanocytes

Shin Ichi Morita, Sota Takanezawa, Akira Date, Shin Watanabe, Yasushi Sako

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Reactive oxygen species generated in dermal cells of human skin is related to skin disorders or diseases. In this study, Raman analysis effectively clarified the identities of three types of human skin models after the models were stimulated with hydrogen peroxide. With the Caucasian skin model, the major Raman bands underwent large intensity changes within 4-5 days of stimulation. With the Black skin model, the Raman bands remained almost unchanged. The changes in the Asian skin model were unique compared to those in the above two. Eumelanin and pheomelanin are probably the main compounds that differentiate dermal cells in terms of their sensitivity to hydrogen peroxide.

Original languageEnglish
Article number903450
JournalJournal of Spectroscopy
Issue number1
Publication statusPublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Spectroscopy

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