Ral GTPases: Crucial mediators of exocytosis and tumourigenesis

Ryutaro Shirakawa; Hisanori Horiuchi

doi:10.1093/jb/mvv029

Ral GTPases: Crucial mediators of exocytosis and tumourigenesis

Ryutaro Shirakawa, Hisanori Horiuchi

Division of Aging Science

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the Ras superfamily of small GTPases. Research on Ral GTPases and their functions over the past 25 years has revealed the essential involvement of these GTPases in unique and diverse cellular processes including exocyst-mediated exocytosis and related cellular activities. Moreover, it is increasingly appreciated that the aberrant activation of Ral GTPases is one of the major causes of human tumourigenesis induced by oncogenic Ras. Recent evidence suggests that Ral signalling pathways may be potential therapeutic targets for the treatment of human cancers. This review summarizes recent advance in the investigation of Ral GTPases.

Original language	English
Pages (from-to)	285-299
Number of pages	15
Journal	Journal of biochemistry
Volume	157
Issue number	5
DOIs	https://doi.org/10.1093/jb/mvv029
Publication status	Published - 2015 May 1

Keywords

Ral
Ras
exocyst
exocytosis
tumourigenesis

ASJC Scopus subject areas

Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jb/mvv029

Cite this

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title = "Ral GTPases: Crucial mediators of exocytosis and tumourigenesis",

abstract = "The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the Ras superfamily of small GTPases. Research on Ral GTPases and their functions over the past 25 years has revealed the essential involvement of these GTPases in unique and diverse cellular processes including exocyst-mediated exocytosis and related cellular activities. Moreover, it is increasingly appreciated that the aberrant activation of Ral GTPases is one of the major causes of human tumourigenesis induced by oncogenic Ras. Recent evidence suggests that Ral signalling pathways may be potential therapeutic targets for the treatment of human cancers. This review summarizes recent advance in the investigation of Ral GTPases.",

keywords = "Ral, Ras, exocyst, exocytosis, tumourigenesis",

author = "Ryutaro Shirakawa and Hisanori Horiuchi",

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AU - Horiuchi, Hisanori

N1 - Funding Information: This work was supported by grants from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (MEXT) to R.S. and H.H. Publisher Copyright: © 2015 The Authors 2015. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

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N2 - The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the Ras superfamily of small GTPases. Research on Ral GTPases and their functions over the past 25 years has revealed the essential involvement of these GTPases in unique and diverse cellular processes including exocyst-mediated exocytosis and related cellular activities. Moreover, it is increasingly appreciated that the aberrant activation of Ral GTPases is one of the major causes of human tumourigenesis induced by oncogenic Ras. Recent evidence suggests that Ral signalling pathways may be potential therapeutic targets for the treatment of human cancers. This review summarizes recent advance in the investigation of Ral GTPases.

AB - The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the Ras superfamily of small GTPases. Research on Ral GTPases and their functions over the past 25 years has revealed the essential involvement of these GTPases in unique and diverse cellular processes including exocyst-mediated exocytosis and related cellular activities. Moreover, it is increasingly appreciated that the aberrant activation of Ral GTPases is one of the major causes of human tumourigenesis induced by oncogenic Ras. Recent evidence suggests that Ral signalling pathways may be potential therapeutic targets for the treatment of human cancers. This review summarizes recent advance in the investigation of Ral GTPases.

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KW - exocyst

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KW - tumourigenesis

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Ral GTPases: Crucial mediators of exocytosis and tumourigenesis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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