Radiosynthesis of O-[11C]methyl-L-tyrosine and O-[18F]Fluoromethyl-L-tyrosine as potential PET tracers for imaging amino acid transport

Ren Iwata, Shozo Furumoto, Claudio Pascali, Anna Bogni, Kiichi Ishiwata

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Two positron-emitting analogues of tyrosine, O-[11C]methyl-L-tyrosine and O- [18F]fluoromethyl-L-tyrosine were prepared as new tumor imaging agents. The alkylating agent, [11C]methyl triflate or [18F]fluoromethyl triflate, was simply bubbled through a dimethylsulfoxide solution of L-tyrosine disodium salt at room temperature. After subsequent HPLC purification the labeled L-tyrosine analogues were obtained in decay-corrected radiochemical yields of over 50%, based on their corresponding labeling agent, with radiochemical purities always higher than 98%. The quite straightforward preparation, together with the high radiochemical yields achieved, make both these syntheses suitable for routine production.

Original languageEnglish
Pages (from-to)555-566
Number of pages12
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume46
Issue number6
DOIs
Publication statusPublished - 2003 May 1

Keywords

  • Amino acid transport
  • C-11
  • F-18
  • O-methyl-L-tyrosine
  • PET
  • Tumor imaging

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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