Radiologic features of pneumonitis associated with nivolumab in non-small-cell lung cancer and malignant melanoma

Tomohisa Baba, Fumikazu Sakai, Terufumi Kato, Masahiko Kusumoto, Hirotsugu Kenmotsu, Hiroaki Sugiura, Junya Tominaga, Katsunori Oikado, Masafumi Sata, Masahiro Endo, Noriyo Yanagawa, Shinichi Sasaki, Tae Iwasawa, Yoshinobu Saito, Yutaka Fujiwara, Yuichiro Ohe, Naoya Yamazaki, Takahiko Sakamoto, Takashi Koshiba, Kazuyoshi Kuwano

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Aim: To assess the clinical features/imaging characteristics of pneumonitis reported during nationwide nivolumab postmarketing surveillance in Japan. Patients & methods: Clinical and radiological data were collected from pneumonitis cases reported during/after nivolumab treatment for melanoma or non-small-cell lung cancer. The expert central review committee evaluated each case. Results: Among 144 cases analyzed, 91 (63.2%) had radiological patterns considered typical for drug-induced pneumonitis and 53 (36.8%) patients had previously unobserved patterns with one or more atypical features, including 23 cases (16.0%) with ground glass opacity confined to the area around the tumor (peritumoral infiltration). A higher proportion of patients with (vs without) peritumoral infiltration had an antitumor response to nivolumab. Conclusion: Images of nivolumab-induced pneumonitis showed previously unobserved radiological patterns.

Original languageEnglish
Pages (from-to)1911-1920
Number of pages10
JournalFuture Oncology
Volume15
Issue number16
DOIs
Publication statusPublished - 2019 Jun

Keywords

  • PD-1 inhibitor
  • immune checkpoint inhibitor
  • interstitial lung disease
  • nivolumab
  • pneumonitis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Radiologic features of pneumonitis associated with nivolumab in non-small-cell lung cancer and malignant melanoma'. Together they form a unique fingerprint.

Cite this