Radical cystectomy for invasive bladder cancer: Results of multi-institutional pooled analysis

Atsushi Takahashi, Taiji Tsukamoto, Ken Ichi Tobisu, Nobuo Shinohara, Kazunari Sato, Yoshihiko Tomita, Shu Ichi Komatsubara, Osamu Nishizawa, Tatsuo Igarashi, Hiroyuki Fujimoto, Hayakazu Nakazawa, Hideki Komatsu, Yoshiki Sugimura, Yoshinari Ono, Masao Kuroda, Osamu Ogawa, Yoshihiko Hirao, Tadashi Hayashi, Tomoyasu Tsushima, Yoshiyuki KakehiYoichi Arai, Sho Ichi Ueda, Masayuki Nakagawa

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Background: We report the outcome of radical cystectomy for patients with invasive bladder cancer, who did not have regional lymph node or distant metastases, at 21 hospitals. Methods: Retrospective, non-randomized, multi-institutional pooled data were analyzed to evaluate outcomes of patients who received radical cystectomy. Between 1991 and 1995, 518 patients with invasive bladder cancer were treated with radical cystectomy at 21 hospitals. Of these, 250 patients (48.3%) received some type of neoadjuvant and/or adjuvant therapy depending on the treatment policy of each hospital. Results: The median follow-up period was 4.4 years, ranging from 0.1 to 11.4 years. The 5-year overall survival rate was 58% for all 518 patients. The 5-year overall survival rates for patients with clinical T2N0M0, T3N0M0 and T4N0M0 were 67%, 52% and 38%, respectively. The patients with pT1 or lower stage, pT2, pT3 and pT4 disease without lymph node metastasis had 5-year overall survivals of 81%, 74%, 47% and 38%, respectively. The patients who were node positive had the worst prognosis, with a 30% overall survival rate at 5 years. Neoadjuvant or adjuvant chemotherapy did not provide a significant survival advantage, although adjuvant chemotherapy improved the 5-year overall survival in patients with pathologically proven lymph node metastasis. Conclusions: The current retrospective study showed that radical cystectomy provided an overall survival equivalent to studies reported previously, but surgery alone had no more potential to prolong survival of patients with invasive cancer. Therefore, a large-scale randomized study on adjuvant treatment as well as development of new strategies will be needed to improve the outcome for patients with invasive bladder cancer.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalJapanese journal of clinical oncology
Issue number1
Publication statusPublished - 2004 Jan 1


  • Invasive bladder cancer
  • Multi-institutional pooled analysis
  • Radical cystectomy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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