Rab32 subfamily small GTPases: Pleiotropic Rabs in endosomal trafficking

Norihiko Ohbayashi, Mitsunori Fukuda, Yasunori Kanaho

    Research output: Contribution to journalReview articlepeer-review

    12 Citations (Scopus)

    Abstract

    Rab small GTPases, well-known regulators of membrane trafficking pathways in eukaryotic cells, comprise approximately 60 different members in mammals. During the past decade, our understanding of the functions of mammalian Rab32 subfamily members (Rab32 and Rab38) have deepened, especially on the biogenesis of lysosome-related organelles, such as melanosomes, and the protection mechanisms against several pathogenic microbial infections. Endosome-mediated membrane trafficking by Rab32 subfamily members plays pivotal roles in these events. In this review, we provide an overview of the regulatory mechanisms of mammalian Rab32-family members in endosomal trafficking, especially focusing on their GEF, GAP and effector molecules, and describe the latest findings on physiological and pathological functions regulated by these molecules.

    Original languageEnglish
    Pages (from-to)65-71
    Number of pages7
    JournalJournal of biochemistry
    Volume162
    Issue number2
    DOIs
    Publication statusPublished - 2017 Aug 1

    Keywords

    • GAP
    • GEF
    • Rab.
    • lysosome-related organelles
    • membrane traffic

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

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