Rab27 and its effectors in secretory granule exocytosis: A novel docking machinery composed of a Rab27 · effector complex

Research output: Contribution to journalShort surveypeer-review

56 Citations (Scopus)

Abstract

A small GTPase Rab27 is present on secretory granules in a wide variety of secretory cells and on melanosomes in melanocytes, and it is involved in controlling the trafficking of these organelles through interaction with a cell-type- or tissue-specific Rab27 effector(s). Slps (synaptotagmin-like proteins) and rabphilin contain an N-terminal Rab27-binding domain and C-terminal tandem C2 domains, and some of the Rab27-binding proteins have recently been shown to promote docking of Rab27-bound organelles to the plasma membrane. This mini-review presents a model for how the Rab27 · effector complex controls the docking step in the trafficking of Rab27-bound organelles. Our results indicate that Slp2-a, Slp4-a/granuphilin-a and rabphilin are capable of interacting with the plasma membrane directly or indirectly, and thus that these Rab27 effectors form a bridge between Rab27-bound organelles and the plasma membrane.

Original languageEnglish
Pages (from-to)691-695
Number of pages5
JournalBiochemical Society Transactions
Volume34
Issue number5
DOIs
Publication statusPublished - 2006 Nov 1

Keywords

  • Docking machinery
  • Melanosome transport
  • Rab27 effector
  • Rabphilin
  • Secretory granule
  • Synaptotagmin-like protein

ASJC Scopus subject areas

  • Biochemistry

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