TY - JOUR
T1 - Rab27 and its effectors in secretory granule exocytosis
T2 - A novel docking machinery composed of a Rab27 · effector complex
AU - Fukuda, M.
PY - 2006/11/1
Y1 - 2006/11/1
N2 - A small GTPase Rab27 is present on secretory granules in a wide variety of secretory cells and on melanosomes in melanocytes, and it is involved in controlling the trafficking of these organelles through interaction with a cell-type- or tissue-specific Rab27 effector(s). Slps (synaptotagmin-like proteins) and rabphilin contain an N-terminal Rab27-binding domain and C-terminal tandem C2 domains, and some of the Rab27-binding proteins have recently been shown to promote docking of Rab27-bound organelles to the plasma membrane. This mini-review presents a model for how the Rab27 · effector complex controls the docking step in the trafficking of Rab27-bound organelles. Our results indicate that Slp2-a, Slp4-a/granuphilin-a and rabphilin are capable of interacting with the plasma membrane directly or indirectly, and thus that these Rab27 effectors form a bridge between Rab27-bound organelles and the plasma membrane.
AB - A small GTPase Rab27 is present on secretory granules in a wide variety of secretory cells and on melanosomes in melanocytes, and it is involved in controlling the trafficking of these organelles through interaction with a cell-type- or tissue-specific Rab27 effector(s). Slps (synaptotagmin-like proteins) and rabphilin contain an N-terminal Rab27-binding domain and C-terminal tandem C2 domains, and some of the Rab27-binding proteins have recently been shown to promote docking of Rab27-bound organelles to the plasma membrane. This mini-review presents a model for how the Rab27 · effector complex controls the docking step in the trafficking of Rab27-bound organelles. Our results indicate that Slp2-a, Slp4-a/granuphilin-a and rabphilin are capable of interacting with the plasma membrane directly or indirectly, and thus that these Rab27 effectors form a bridge between Rab27-bound organelles and the plasma membrane.
KW - Docking machinery
KW - Melanosome transport
KW - Rab27 effector
KW - Rabphilin
KW - Secretory granule
KW - Synaptotagmin-like protein
UR - http://www.scopus.com/inward/record.url?scp=33751290691&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751290691&partnerID=8YFLogxK
U2 - 10.1042/BST0340691
DO - 10.1042/BST0340691
M3 - Short survey
C2 - 17052176
AN - SCOPUS:33751290691
VL - 34
SP - 691
EP - 695
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
SN - 0300-5127
IS - 5
ER -