Quinolone derivatives: Synthesis and binding evaluation on cholecystokinin receptors

A. Varnavas, L. Lassiani, E. Luxich, M. Zacchigna, E. Boccu, F. Pichierri

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A series of 1,2-dihydro-4-phenylquinolin-2-one-3-carboxylic acid and of 3-amino-4-phenylcarbostyril derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-A rather than CCK-B receptor and the results have been discussed on the basis of a molecular modelling study.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalFarmaco
Volume51
Issue number5
Publication statusPublished - 1996 Jul 4
Externally publishedYes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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  • Cite this

    Varnavas, A., Lassiani, L., Luxich, E., Zacchigna, M., Boccu, E., & Pichierri, F. (1996). Quinolone derivatives: Synthesis and binding evaluation on cholecystokinin receptors. Farmaco, 51(5), 341-350.