Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases

Daisuke Takahashi, Yuki Orihara, Saho Kitagawa, Masayuki Kusakabe, Takahiro Shintani, Yukako Oma, Masahiko Harata

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Quantitative control of histones and histone variants during cell cycle is relevant to their epigenetic functions. We found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. Overexpression of H2A.Z induced defects in mitotic progression, suggesting functional importance of this quantitative control.

    Original languageEnglish
    Pages (from-to)1557-1560
    Number of pages4
    JournalBioscience, Biotechnology and Biochemistry
    Volume81
    Issue number8
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Chromatin
    • H2A.Z
    • Histone
    • SUMO-targeted ubiquitin ligases

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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