Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases

Daisuke Takahashi, Yuki Orihara, Saho Kitagawa, Masayuki Kusakabe, Takahiro Shintani, Yukako Oma, Masahiko Harata

Research output: Contribution to journalArticle

Abstract

Quantitative control of histones and histone variants during cell cycle is relevant to their epigenetic functions. We found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. Overexpression of H2A.Z induced defects in mitotic progression, suggesting functional importance of this quantitative control.

Original languageEnglish
Pages (from-to)1557-1560
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume81
Issue number8
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • Chromatin
  • H2A.Z
  • Histone
  • SUMO-targeted ubiquitin ligases

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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