Quantitative nano-bio-imaging of cancer disease state

Kohsuke Gonda, Naoko Furusawa, Yasushi Nakano, Yoshio Kobayashi

Research output: Contribution to journalReview articlepeer-review

Abstract

The studies to apply imaging with nanoparticles to an elucidation of a mechanism of cancer or a development of diagnostic technology of cancer have received a lot of attention in recent years. We created novel nanoperticles which possess fluorescence or X-ray absorption and then combined such technology with own of optical system and image analysis system for development of quantitative nano-bio-imaging, in order to visualize disease state of cancer. In this review paper, we introduce three topics of cancer studies using the nano-bio-imaging. The first topic is analysis of mechanisms of cancer metastasis. We have developed a method for in vivo imaging with very high spatial accuracy(~9 nm)using quantum dots and succeeded in tracking the membrane protein during metastasis in living mice. The second topic is development of a cancer detection method. We created gold nanoparticles conjugated with polyethylene glycol chains as a new contrast agent and succeeded in imaging millimeter-sized microtumors with X-ray computed tomography by injecting the nanoparticles into tumor-bearing mice. The third topic is development of technology to predict drug efficacy in chemotherapy given before surgery of human breast cancer. We created organic fluorophore assembly-conjugated nanoparticles suitable for immunohistochemistry and applied the nanoparticles to categorize the response to molecular target-based drug therapy in breast cancer patients. We hope that these topics are useful to the reader.

Original languageEnglish
Pages (from-to)179-189
Number of pages11
JournalDrug Delivery System
Volume33
Issue number3
DOIs
Publication statusPublished - 2018

Keywords

  • Cancer
  • Fluorescence
  • Imaging
  • Nanoparticle
  • X-ray

ASJC Scopus subject areas

  • Pharmaceutical Science

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