Quantitative assessment of myocardial enhancement with iodinated contrast medium in patients with ischemic heart disease by using ultrafast X-ray computed tomography

Hiroaki Naito, Haruo Saito, Makoto Takamiya, Seiki Hamada, Naoaki Yamada, Satoshi Imakita, Mitsushige Ohta, Kohji Kimura, Shinichi Tamura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

BACKGROUND AND RATIONALE The authors report the quantitation of myocardial enhancement using iodinated contrast medium in patients with ischemic heart disease. Twenty-eight patients with chronic ischemic heart disease and 11 controls were examined by ultrafast computed tomography (CT) using 100-msecond scans. METHODS The authors analyzed M/L (ratio of post-contrast incremental increases in the left ventricular myocardial and luminal CT number) in early and late phases after contrast injection. RESULTS In controls, mean values of early and late M/L were 30% and 51%, respectively. In infarcted or severly ischemic segments, early M/Ls (19%, 16%) were significantly small (P < .001), whereas late M/Ls (90%, 63%) were higher (P < .001, .01) than controls. Segments with infarction or severe ischemia were differentiated from mild or nonsignificant ischemia by using this parameter (sensitivity, 99%; specificity, 88%).

Original languageEnglish
Pages (from-to)436-442
Number of pages7
JournalInvestigative Radiology
Volume27
Issue number6
DOIs
Publication statusPublished - 1992 Jun
Externally publishedYes

Keywords

  • Iodinated contrast medium
  • Ischemic heart disease
  • Myocardial infarction
  • Myocardial ischemia
  • Ultrafast computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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