Quantitative analysis of acetone in breath using vacuum-ultraviolet spectroscopy based on hollow-optical-fiber gas cell

Y. Kudo, Y. Matsuura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A vacuum-ultraviolet (VUV) spectroscopy system is proposed for measurement of acetone in human breath that has been attracting attention as a biomarker of body fat metabolism and diagnosis of diabetes. A strong absorption peak of acetone at 195 nm is detected by using a simple system consisting of a deuterium lamp source, a hollow-core fiber gas cell, and a fiber-coupled compact spectrometer corresponding the VUV region. The hollow-core fiber functions as a long path and extremely small volume gas cell and enables sensitive measurement of trace components in exhaled breath. For breath analysis, we applied multiple regression analysis using absorption spectra of O2, H2O, and the acetone standard gas as explanatory variables to quantitate the concentration of acetone in breath. We applied standard addition method based on human breath and as a result, it was found that the measurement accuracy was 0.074 ppm in standard deviation (SD) for healthy human breath with the acetone concentration of around 0.8 ppm and precision was 0.026 ppm SD. We also tried to monitor body fat burn based on breath acetone and confirmed that breath acetone increased after exercises because acetone is a volatile byproduct of lipolysis.

Original languageEnglish
Title of host publicationOptical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI
EditorsIsrael Gannot, Katy Roodenko
PublisherSPIE
ISBN (Electronic)9781510641051
DOIs
Publication statusPublished - 2021
EventOptical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI 2021 - Virtual, Online, United States
Duration: 2021 Mar 62021 Mar 11

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11635
ISSN (Print)1605-7422

Conference

ConferenceOptical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI 2021
Country/TerritoryUnited States
CityVirtual, Online
Period21/3/621/3/11

Keywords

  • Breath acetone measurement
  • Hollow optical fiber
  • Vacuum ultraviolet spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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