Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinsons disease in mice

Satomi Kikuta, Yukiyo Nakamura, Yukio Yamamura, Atsushi Tamura, Noriyasu Homma, Yuchio Yanagawa, Hajime Tamura, Jiro Kasahara, Makoto Osanai

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinsons disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.

Original languageEnglish
Article number12800
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015 Aug 10

ASJC Scopus subject areas

  • General

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