Quantification of renal function with 99mTc-MAG3 - Quantification of tubular extraction rate using Bubeck's method

Tetsuro Yamazaki, S. Maruoka, K. Sakamoto

Research output: Contribution to journalArticlepeer-review

Abstract

99mTc-mercaptoacetyltriglycine (MAG3) is a new agent for dynamic renal scintigraphy. It provides not only superior quality of imaging to conventional agents such as 131-orthoiodohippurate or 99mTc- demethylenetriaminepantaacetic acid but also quantification of renal function as do the latter agents. The aim of the present study was to evaluate the values of the tubular extraction rate (TER) using 99mTc-MAG3 calculated by Bubeck's method, a simple technique for quantifying renal function. In 31 patients with renal disorders, we compared the TER thus obtained with laboratory data, plasma paraaminohippurate clearance, effective renal plasma flow calculated by Tauxe's method, and plasma 99mTc-MAG3 clearance calculated according to the two-compartment model. TER was easily applicable in clinical settings, and showed close parallels with the other indexes of renal function. We believe, therefore, that it can serve ass a useful parameter of renal function.

Original languageEnglish
Pages (from-to)1199-1206
Number of pages8
JournalKakuigaku
Volume32
Issue number11
Publication statusPublished - 1995 Dec 1

Keywords

  • Tc-MAG3
  • Dynamic renal scintigraphy
  • Renal function
  • Tubular extraction rate (TER)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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