Quality of life in patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time: Comparison between patients on psychostimulants, drug-naïve patients and the general Japanese population

Akiko Ozaki, Yuichi Inoue, Kenichi Hayashida, Toru Nakajima, Makoto Honda, Akira Usui, Yoko Komada, Mina Kobayashi, Kiyohisa Takahashi

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Objective: To assess the quality of life of patients with narcolepsy with cataplexy (NA-CA), narcolepsy without cataplexy (NA w/o CA), and idiopathic hypersomnia without long sleep time (IHS w/o LST) who were taking psychostimulant medication, and to ascertain which factors (including psychosocial and environmental variables) influence quality of life in this population. Methods: In total, 185 patients who had received regular treatment were enrolled in the study (NA-CA, n= 83; NA w/o CA, n= 48; IHS w/o LST, n= 54). Patients were asked to complete questionnaires including the Short Form-36 Health Survey (SF-36), the Epworth Sleepiness Scale (ESS), and items concerning psychosocial and environmental variables. Results: All three diagnostic groups had significantly lower scores for most SF-36 domains compared with the Japanese normative data, and the ESS score was significantly reduced with treatment. Multiple logistic regression analyses revealed that several SF-36 domains were associated with the ESS score; autonomy in controlling own job schedule, experience of divorce or break up with a partner due to symptoms, experience of being forced to relocate or being dismissed due to symptoms, and perception of support from others. Conclusions: The severity of subjective sleepiness and psychological and environmental variables influenced quality of life in patients with these hypersomnias of central origin.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalSleep Medicine
Volume13
Issue number2
DOIs
Publication statusPublished - 2012 Feb
Externally publishedYes

Keywords

  • Environmental factors
  • Idiopathic hypersomnia without long sleep time
  • Narcolepsy with cataplexy
  • Narcolepsy without cataplexy
  • Psychosocial factors
  • Psychostimulants
  • Quality of life
  • SF-36

ASJC Scopus subject areas

  • Medicine(all)

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