TY - JOUR
T1 - Quality of Life and Problems Affecting Recipients More Than 10 Years After Living Donor Liver Transplantation
AU - Kawagishi, N.
AU - Takeda, I.
AU - Miyagi, S.
AU - Satoh, K.
AU - Akamatsu, Y.
AU - Sekiguchi, S.
AU - Satomi, S.
PY - 2009/1
Y1 - 2009/1
N2 - Background: We initiated living donor liver transplantation (LDLT) in 1991, allowing us to examine issues related to long-term survival. The aim of this study was to review the long-term outcomes of LDLT in children. Patients and Methods: We performed 116 LDLT from 1991 to present, including 17 recipients who survived >10 years. They were evaluated for growth, immunosuppressive therapy, complications, and quality of life (QOL). Results: The average age at LDLT was 5.4 years (range, 6 months to 17 years), with a present average age of 17.2 years (range, 11-28 years). At the time of LDLT, 6 recipients had growth retardation with body weights low for age by 2 standard deviations (SD). However, 4 of 6 recipients who underwent LDLT before age of 2 years caught up, reaching average heights and body weights for their ages. Among 6 recipients who were diagnosed with acute rejections by biopsy >5 years after LDLT, 5 improved after steroid pulse therapy. One recipient with a steroid-resistant acute rejection was administered deoxyspergualin after steroids. Chronic rejection was not observed in this series. One recipient has not required immunosuppressive therapy for >4 years with a good present condition. Conclusion: The majority of LDLT recipients achieved a good QOL during long-term survival; they are pursuing normal studies.
AB - Background: We initiated living donor liver transplantation (LDLT) in 1991, allowing us to examine issues related to long-term survival. The aim of this study was to review the long-term outcomes of LDLT in children. Patients and Methods: We performed 116 LDLT from 1991 to present, including 17 recipients who survived >10 years. They were evaluated for growth, immunosuppressive therapy, complications, and quality of life (QOL). Results: The average age at LDLT was 5.4 years (range, 6 months to 17 years), with a present average age of 17.2 years (range, 11-28 years). At the time of LDLT, 6 recipients had growth retardation with body weights low for age by 2 standard deviations (SD). However, 4 of 6 recipients who underwent LDLT before age of 2 years caught up, reaching average heights and body weights for their ages. Among 6 recipients who were diagnosed with acute rejections by biopsy >5 years after LDLT, 5 improved after steroid pulse therapy. One recipient with a steroid-resistant acute rejection was administered deoxyspergualin after steroids. Chronic rejection was not observed in this series. One recipient has not required immunosuppressive therapy for >4 years with a good present condition. Conclusion: The majority of LDLT recipients achieved a good QOL during long-term survival; they are pursuing normal studies.
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U2 - 10.1016/j.transproceed.2008.08.139
DO - 10.1016/j.transproceed.2008.08.139
M3 - Article
C2 - 19249523
AN - SCOPUS:60649085819
VL - 41
SP - 236
EP - 237
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 1
ER -