Quality of Life and Problems Affecting Recipients More Than 10 Years After Living Donor Liver Transplantation

N. Kawagishi, I. Takeda, S. Miyagi, K. Satoh, Y. Akamatsu, S. Sekiguchi, S. Satomi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background: We initiated living donor liver transplantation (LDLT) in 1991, allowing us to examine issues related to long-term survival. The aim of this study was to review the long-term outcomes of LDLT in children. Patients and Methods: We performed 116 LDLT from 1991 to present, including 17 recipients who survived >10 years. They were evaluated for growth, immunosuppressive therapy, complications, and quality of life (QOL). Results: The average age at LDLT was 5.4 years (range, 6 months to 17 years), with a present average age of 17.2 years (range, 11-28 years). At the time of LDLT, 6 recipients had growth retardation with body weights low for age by 2 standard deviations (SD). However, 4 of 6 recipients who underwent LDLT before age of 2 years caught up, reaching average heights and body weights for their ages. Among 6 recipients who were diagnosed with acute rejections by biopsy >5 years after LDLT, 5 improved after steroid pulse therapy. One recipient with a steroid-resistant acute rejection was administered deoxyspergualin after steroids. Chronic rejection was not observed in this series. One recipient has not required immunosuppressive therapy for >4 years with a good present condition. Conclusion: The majority of LDLT recipients achieved a good QOL during long-term survival; they are pursuing normal studies.

Original languageEnglish
Pages (from-to)236-237
Number of pages2
JournalTransplantation Proceedings
Volume41
Issue number1
DOIs
Publication statusPublished - 2009 Jan

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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