Pupil dilatation assay by tropicamide is modulated by apolipoprotein e ∈4 allele dosage in Alzheimer's disease

Hiroyuki Arai; Masanori Terajima; Takuma Nakagawa; Susumu Higuchi; Hiroshi Mochizuki; Hidetada Sasaki

doi:10.1097/00001756-199603220-00017

Pupil dilatation assay by tropicamide is modulated by apolipoprotein e ∈4 allele dosage in Alzheimer's disease

Hiroyuki Arai, Masanori Terajima, Takuma Nakagawa, Susumu Higuchi, Hiroshi Mochizuki, Hidetada Sasaki

Division of Brain Science

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

THE mydriatic response to dilute tropicamide was studied in 25 Japanese patients with Alzheimer's disease (AD), 13 patients with non-AD neurological diseases (non-AD) and 11 normal elderly subjects (control). Although the changes in resting pupil diameter and area over baseline were significantly greater (p < 0.05) in AD patients than in non-AD patients and controls, there was considerable overlap between the three groups. The change in resting pupil area was significantly greater (p < 0.05) in AD patients homozygous for ApoE ∈4 than in AD patients heterozygous for or without this allele. Despite a limited sample size in the present study, our results indicate that the pupil dilation assay by tropicamide is not an effective diagnostic tool for AD, and it may be modulated by different gene dosage of ApoE ∈4.

Original language	English
Pages (from-to)	918-920
Number of pages	3
Journal	NeuroReport
Volume	7
Issue number	4
DOIs	https://doi.org/10.1097/00001756-199603220-00017
Publication status	Published - 1996

Keywords

Alzheimer's disease
Apolipoprotcin E gene
Pupil assay
Tropicamide

ASJC Scopus subject areas

Neuroscience(all)

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title = "Pupil dilatation assay by tropicamide is modulated by apolipoprotein e ∈4 allele dosage in Alzheimer's disease",

abstract = "THE mydriatic response to dilute tropicamide was studied in 25 Japanese patients with Alzheimer's disease (AD), 13 patients with non-AD neurological diseases (non-AD) and 11 normal elderly subjects (control). Although the changes in resting pupil diameter and area over baseline were significantly greater (p < 0.05) in AD patients than in non-AD patients and controls, there was considerable overlap between the three groups. The change in resting pupil area was significantly greater (p < 0.05) in AD patients homozygous for ApoE ∈4 than in AD patients heterozygous for or without this allele. Despite a limited sample size in the present study, our results indicate that the pupil dilation assay by tropicamide is not an effective diagnostic tool for AD, and it may be modulated by different gene dosage of ApoE ∈4.",

keywords = "Alzheimer's disease, Apolipoprotcin E gene, Pupil assay, Tropicamide",

author = "Hiroyuki Arai and Masanori Terajima and Takuma Nakagawa and Susumu Higuchi and Hiroshi Mochizuki and Hidetada Sasaki",

year = "1996",

doi = "10.1097/00001756-199603220-00017",

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T1 - Pupil dilatation assay by tropicamide is modulated by apolipoprotein e ∈4 allele dosage in Alzheimer's disease

AU - Arai, Hiroyuki

AU - Terajima, Masanori

AU - Nakagawa, Takuma

AU - Higuchi, Susumu

AU - Mochizuki, Hiroshi

AU - Sasaki, Hidetada

PY - 1996

Y1 - 1996

N2 - THE mydriatic response to dilute tropicamide was studied in 25 Japanese patients with Alzheimer's disease (AD), 13 patients with non-AD neurological diseases (non-AD) and 11 normal elderly subjects (control). Although the changes in resting pupil diameter and area over baseline were significantly greater (p < 0.05) in AD patients than in non-AD patients and controls, there was considerable overlap between the three groups. The change in resting pupil area was significantly greater (p < 0.05) in AD patients homozygous for ApoE ∈4 than in AD patients heterozygous for or without this allele. Despite a limited sample size in the present study, our results indicate that the pupil dilation assay by tropicamide is not an effective diagnostic tool for AD, and it may be modulated by different gene dosage of ApoE ∈4.

AB - THE mydriatic response to dilute tropicamide was studied in 25 Japanese patients with Alzheimer's disease (AD), 13 patients with non-AD neurological diseases (non-AD) and 11 normal elderly subjects (control). Although the changes in resting pupil diameter and area over baseline were significantly greater (p < 0.05) in AD patients than in non-AD patients and controls, there was considerable overlap between the three groups. The change in resting pupil area was significantly greater (p < 0.05) in AD patients homozygous for ApoE ∈4 than in AD patients heterozygous for or without this allele. Despite a limited sample size in the present study, our results indicate that the pupil dilation assay by tropicamide is not an effective diagnostic tool for AD, and it may be modulated by different gene dosage of ApoE ∈4.

KW - Alzheimer's disease

KW - Apolipoprotcin E gene

KW - Pupil assay

KW - Tropicamide

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Pupil dilatation assay by tropicamide is modulated by apolipoprotein e ∈4 allele dosage in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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