TY - JOUR
T1 - Pulse-waveform analysis of normal population using laser speckle flowgraphy
AU - Tsuda, Satoru
AU - Kunikata, Hiroshi
AU - Shimura, Masahiko
AU - Aizawa, Naoko
AU - Omodaka, Kazuko
AU - Shiga, Yukihiro
AU - Yasuda, Masayuki
AU - Yokoyama, Yu
AU - Nakazawa, Toru
N1 - Publisher Copyright:
© 2014 Informa Healthcare USA, Inc. All rights reserved.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Purpose: Laser speckle flowgraphy (LSFG), a new, non-invasive method of measuring the mean blur rate (MBR) of ocular blood flow, allows for the analysis of the pulse waveform of a heartbeat as it changes dynamically. Here, we investigated the relationship between the pulse waveform and clinical parameters, particularly age. Materials and methods: Sixty eyes of 60 healthy subjects without diabetes were enrolled from among patients undergoing annual health examinations. LSFG, and its analysis software, were used to determine pulse waveform parameters including MBR, skew, blowout score (BOS), blowout time (BOT), rising rate and falling rate in the optic nerve head (ONH), both specifically in the tissue area and in the ONH overall. Fifteen clinical parameters were also recorded, including age and blood pressure, as well as triglyceride and creatinine levels. Results: Skew, BOT and falling rate had a strong correlation (r>0.60) with age, but not with the other clinical parameters. This correlation with age was stronger in the tissue area (BOT: p<0.0001, r=-0.68; skew: p<0.0001, r=0.65; falling rate: p<0.0001, r=0.61) than in the ONH overall (BOT: p<0.0001, r=-0.67; skew: p<0.0001, r=0.60; falling rate: p<0.0001, r=0.59). Stepwise multiple regression analysis revealed that tissue area falling rate was an independent factor indicating age, and conversely that age was an independent factor indicating tissue area falling rate. Conclusions: The significant correlation of LSFG-measured tissue area falling rate with age suggests that it may be a new candidate biomarker for age-dependent microcirculation.
AB - Purpose: Laser speckle flowgraphy (LSFG), a new, non-invasive method of measuring the mean blur rate (MBR) of ocular blood flow, allows for the analysis of the pulse waveform of a heartbeat as it changes dynamically. Here, we investigated the relationship between the pulse waveform and clinical parameters, particularly age. Materials and methods: Sixty eyes of 60 healthy subjects without diabetes were enrolled from among patients undergoing annual health examinations. LSFG, and its analysis software, were used to determine pulse waveform parameters including MBR, skew, blowout score (BOS), blowout time (BOT), rising rate and falling rate in the optic nerve head (ONH), both specifically in the tissue area and in the ONH overall. Fifteen clinical parameters were also recorded, including age and blood pressure, as well as triglyceride and creatinine levels. Results: Skew, BOT and falling rate had a strong correlation (r>0.60) with age, but not with the other clinical parameters. This correlation with age was stronger in the tissue area (BOT: p<0.0001, r=-0.68; skew: p<0.0001, r=0.65; falling rate: p<0.0001, r=0.61) than in the ONH overall (BOT: p<0.0001, r=-0.67; skew: p<0.0001, r=0.60; falling rate: p<0.0001, r=0.59). Stepwise multiple regression analysis revealed that tissue area falling rate was an independent factor indicating age, and conversely that age was an independent factor indicating tissue area falling rate. Conclusions: The significant correlation of LSFG-measured tissue area falling rate with age suggests that it may be a new candidate biomarker for age-dependent microcirculation.
KW - BOT
KW - Falling rate
KW - Laser speckle flowgraphy
KW - Mean blur rate
KW - Normal population
KW - Ocular blood flow
KW - Pulse-waveform analysis
KW - Skew
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U2 - 10.3109/02713683.2014.905608
DO - 10.3109/02713683.2014.905608
M3 - Article
C2 - 24749668
AN - SCOPUS:84909947116
VL - 39
SP - 1207
EP - 1215
JO - Current Eye Research
JF - Current Eye Research
SN - 0271-3683
IS - 12
ER -