[Pulmonary MAC disease and the mycobacterial genotyping].

Toshiaki Kikuchi

Research output: Contribution to journalReview articlepeer-review


Although pulmonary MAC disease tends to have variable disease progression, predictors related to disease progression have not been fully established. With this background, we evaluated variable numbers of tandem repeats (VNTR) in 16 mycobacterial interspersed repetitive unit loci of M. avium clinical isolates from respiratory specimens. Cluster analysis of the VNTR data showed that M. avium isolates from progressive versus stable lung disease grouped together in distinct clusters. In further analysis of logistic regression modeling, the progression of pulmonary MAC disease could be predicted by using a best-fit model. The data demonstrate that disease progression of pulmonary MAC disease is significantly associated with the M. avium genotyping.

Original languageEnglish
Pages (from-to)1444-1448
Number of pages5
JournalNihon rinsho. Japanese journal of clinical medicine
Issue number8
Publication statusPublished - 2011 Aug 1

ASJC Scopus subject areas

  • Medicine(all)


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