Pulmonary fibrosis after endotoxin-induced permeability edema

K. Koike, M. Chida, S. Suzuki, Y. Ashino, Y. Kubo, K. Isogami, G. Nasu, S. Ono, Y. Sagara, T. Sakuma

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3 Citations (Scopus)


To know the pathogenesis of the lung fibrosis after ARDS, we investigated the role of PMN-elastase after endotoxin-induced pulmonary edema in awake sheep with chronic lung lymph fistulas. The permeability of the pulmonary circulation increased 2 hours after endotoxin injection. Four hours after endotoxin injection, WBC migrated to the lung interstitium and the number of WBC in BALF increased. Endotoxin increased PMN-elastase in plasma and lymph whereas the level of alpha-1-protease inhibitor (alpha-1-PI) did not change. The activity of alpha-1-PI measured by trypsin inhibitory capacity was zero in the exudative phase. The level of PMN-elastase in lymph was significantly higher 1 week after endotoxin injection than baseline levels. Histologically, pulmonary fibrosis developed 1 week after endotoxin injection. These results suggest that inflammatory mediators released from PMN play an important part in progress to the fibrotic phase after ARDS.

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalJapanese Journal of Thoracic Diseases
Issue number4
Publication statusPublished - 1989 Apr 1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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