Pulmonary cryptococcosis treated by combination therapy of fluconazole plus flucytosine

K. I. Tanaka, S. Kohno, S. Maesaki, K. Mitsutake, H. Miyazaki, T. Miyazaki, K. Tomono, M. Kaku, H. Koga, K. Hara

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The efficacy of the combination therapy of fluconazole plus flucytosine against pulmonary cryptococcosis was investigated. The minimal inhibitory concentrations of antifungal agents were measured by growth inhibition on Yeast-morphology agar plates, and the fractional inhibitory concentration index of each antifungal combination were calculated by checker-board titration. Eight of Cryptococcus neoformans clinical isolates showed sensitivity for AMPH, 5-FC, MCZ and ITZ. C. neoformans showed resistance against FLCZ. The combination of FLCZ plus 5-FC showed synergistic effect against C. neoformans. Three cases of pulmonary cryptococcosis were treated by combination therapy of fluconazole plus flucytosine. After treatment, C. neoformans isolates were eradicated and the chest X-ray improved remarkably. The combination therapy of fluconazole plus flucytosine was effective for the treatment of pulmonary cryptococcosis.

Original languageEnglish
Pages (from-to)1528-1533
Number of pages6
JournalJapanese Journal of Thoracic Diseases
Volume31
Issue number12
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Pulmonary cryptococcosis treated by combination therapy of fluconazole plus flucytosine'. Together they form a unique fingerprint.

Cite this