PTPRT regulates high-fat diet-induced obesity and insulin resistance

Xiujing Feng, Anthony Scott, Yong Wang, Lan Wang, Yiqing Zhao, Stephanie Doerner, Masanobu Satake, Colleen M. Croniger, Zhenghe Wang

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Obesity is a risk factor for many human diseases. However, the underlying molecular causes of obesity are not well understood. Here, we report that protein tyrosine phosphatase receptor T (PTPRT) knockout mice are resistant to high-fat diet-induced obesity. Those mice avoid many deleterious side effects of high-fat diet-induced obesity, displaying improved peripheral insulin sensitivity, lower blood glucose and insulin levels. Compared to wild type littermates, PTPRT knockout mice show reduced food intake. Consistently, STAT3 phosphorylation is up-regulated in the hypothalamus of PTPRT knockout mice. These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity.

Original languageEnglish
Article numbere100783
JournalPloS one
Volume9
Issue number6
DOIs
Publication statusPublished - 2014 Jun 20

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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