Abstract
We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 ± 7 nM (pH 7.0, T = 20°C). The significant effect of the guanidino group attached to the pteridine ring on the binding selectivity and affinity is discussed based on the examination of thermodynamic parameters.
Original language | English |
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Pages (from-to) | 982-984 |
Number of pages | 3 |
Journal | Chemistry Letters |
Volume | 45 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2016 |
Keywords
- Fluorescence sensing
- Orphan guanine
- RNA-binding ligand
ASJC Scopus subject areas
- Chemistry(all)