Abstract
We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 ± 7 nM (pH 7.0, T = 20°C). The significant effect of the guanidino group attached to the pteridine ring on the binding selectivity and affinity is discussed based on the examination of thermodynamic parameters.
| Original language | English |
|---|---|
| Pages (from-to) | 982-984 |
| Number of pages | 3 |
| Journal | Chemistry Letters |
| Volume | 45 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2016 Jan 1 |
Keywords
- Fluorescence sensing
- Orphan guanine
- RNA-binding ligand
ASJC Scopus subject areas
- Chemistry(all)
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Sato, Y., Asami, T., Toriyabe, Y., Sato, T., Teramae, N., & Nishizawa, S. (2016). Pteridine derivatives modified with a guanidine for binding and sensing an orphan guanine in RNA duplexes. Chemistry Letters, 45(8), 982-984. https://doi.org/10.1246/cl.160425