Pteridine derivatives modified with a guanidine for binding and sensing an orphan guanine in RNA duplexes

Yusuke Sato, Takahiro Asami, Yu Toriyabe, Takaya Sato, Norio Teramae, Seiichi Nishizawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 ± 7 nM (pH 7.0, T = 20°C). The significant effect of the guanidino group attached to the pteridine ring on the binding selectivity and affinity is discussed based on the examination of thermodynamic parameters.

Original languageEnglish
Pages (from-to)982-984
Number of pages3
JournalChemistry Letters
Volume45
Issue number8
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Fluorescence sensing
  • Orphan guanine
  • RNA-binding ligand

ASJC Scopus subject areas

  • Chemistry(all)

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