Pteridine derivatives modified with a guanidine for binding and sensing an orphan guanine in RNA duplexes

Yusuke Sato; Takahiro Asami; Yu Toriyabe; Takaya Sato; Norio Teramae; Seiichi Nishizawa

doi:10.1246/cl.160425

Pteridine derivatives modified with a guanidine for binding and sensing an orphan guanine in RNA duplexes

Yusuke Sato, Takahiro Asami, Yu Toriyabe, Takaya Sato, Norio Teramae, Seiichi Nishizawa

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 ± 7 nM (pH 7.0, T = 20°C). The significant effect of the guanidino group attached to the pteridine ring on the binding selectivity and affinity is discussed based on the examination of thermodynamic parameters.

Original language	English
Pages (from-to)	982-984
Number of pages	3
Journal	Chemistry Letters
Volume	45
Issue number	8
DOIs	https://doi.org/10.1246/cl.160425
Publication status	Published - 2016

Keywords

Fluorescence sensing
Orphan guanine
RNA-binding ligand

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.160425

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abstract = "We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 ± 7 nM (pH 7.0, T = 20°C). The significant effect of the guanidino group attached to the pteridine ring on the binding selectivity and affinity is discussed based on the examination of thermodynamic parameters.",

keywords = "Fluorescence sensing, Orphan guanine, RNA-binding ligand",

author = "Yusuke Sato and Takahiro Asami and Yu Toriyabe and Takaya Sato and Norio Teramae and Seiichi Nishizawa",

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language = "English",

volume = "45",

pages = "982--984",

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TY - JOUR

T1 - Pteridine derivatives modified with a guanidine for binding and sensing an orphan guanine in RNA duplexes

AU - Sato, Yusuke

AU - Asami, Takahiro

AU - Toriyabe, Yu

AU - Sato, Takaya

AU - Teramae, Norio

AU - Nishizawa, Seiichi

PY - 2016

Y1 - 2016

N2 - We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 ± 7 nM (pH 7.0, T = 20°C). The significant effect of the guanidino group attached to the pteridine ring on the binding selectivity and affinity is discussed based on the examination of thermodynamic parameters.

AB - We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 ± 7 nM (pH 7.0, T = 20°C). The significant effect of the guanidino group attached to the pteridine ring on the binding selectivity and affinity is discussed based on the examination of thermodynamic parameters.

KW - Fluorescence sensing

KW - Orphan guanine

KW - RNA-binding ligand

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UR - http://www.scopus.com/inward/citedby.url?scp=84982969065&partnerID=8YFLogxK

U2 - 10.1246/cl.160425

DO - 10.1246/cl.160425

M3 - Article

AN - SCOPUS:84982969065

VL - 45

SP - 982

EP - 984

JO - Chemistry Letters

JF - Chemistry Letters

SN - 0366-7022

IS - 8

ER -

Pteridine derivatives modified with a guanidine for binding and sensing an orphan guanine in RNA duplexes

Abstract

Keywords

ASJC Scopus subject areas

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