PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma

Hideaki Kato, Miki Fujimura, Toshihiro Kumabe, Chikashi Ishioka, Ryunosuke Kanamaru, Takashi Yoshimoto

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Dissemination of glioblastomas is often observed, but the underlying mechanism is not well clarified especially from the genetic viewpoints. The present study examined whether PTEN gene mutations and MIB-1 labeling index (LI) correlate with the dissemination in 39 consecutive patients with glioblastomas. Dissemination was defined as leptomenigeal enhancement by magnetic resonance imaging performed in all patients every 2-3 months. We examined PTEN mutations in 26 patients using cDNA-based direct sequencing and MIB-1 LI in 38 patients. Median survival time of the 39 patients was 16.2 months. Dissemination was found in 17 of 39 patients (43.6%). PTEN mutation was significantly associated with dissemination (P=0.0140), and higher MIB-1 LI (≥:35%) resulted in earlier dissemination (P=0.0156). Kaplan-Meier survival plots showed a significantly poorer survival for patients with PTEN mutation (P=0.0012). The results indicate that the evaluation of PTEN mutation and MIB-1 LI are useful to predict dissemination and prognosis of glioblastomas.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalJournal of Clinical Neuroscience
Volume11
Issue number1
DOIs
Publication statusPublished - 2004 Jan

Keywords

  • Dissemination
  • Glioblastoma
  • MIB-1 labeling index
  • PTEN
  • Prognosis

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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