Pseurotin A and its analogues as inhibitors of immunoglobuline E production

Minoru Ishikawa, Tomohisa Ninomiya, Hirotomo Akabane, Nobuaki Kushida, Go Tsujiuchi, Makoto Ohyama, Shuichi Gomi, Keiko Shito, Takashi Murata

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC50 of 0.066 μM. An immunosuppressive activity of another natural product, synerazol was also found.

Original languageEnglish
Pages (from-to)1457-1460
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number5
DOIs
Publication statusPublished - 2009 Mar 1

Keywords

  • 10-Deoxypseurotin A
  • Immunosuppressive activity
  • Inhibitor of IgE production
  • Pseurotin A
  • Structure-activity relationship
  • Synerazol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Ishikawa, M., Ninomiya, T., Akabane, H., Kushida, N., Tsujiuchi, G., Ohyama, M., Gomi, S., Shito, K., & Murata, T. (2009). Pseurotin A and its analogues as inhibitors of immunoglobuline E production. Bioorganic and Medicinal Chemistry Letters, 19(5), 1457-1460. https://doi.org/10.1016/j.bmcl.2009.01.029