Proteomics search of influenza A viruses for adaptive mutations to human hosts

Yuki Furuse, Hitoshi Oshitani

Research output: Contribution to journalComment/debatepeer-review


Evaluation of: Miotto O, Heiny AT, Albrecht R et al. Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains. PLoS ONE 5(2), e9025 (2010). The emergence of an influenza pandemic is of great concern globally. It is, therefore, necessary to have a better understanding of the adaptation of influenza A viruses to humans. The mutation patterns affecting host tropism may provide information on the mechanisms and determinants of the host barrier. The work by Miotto et al. describes a catalog of mutations observed specifically in human influenza A viruses by analyzing almost 100,000 influenza A virus protein sequences. These sites may be important for host tropism and characteristic mutations of human influenza viruses may be required for efficient human-to-human transmission. The catalog can be used for genetic surveillance of zoonotic strains of the influenza A virus to determine their pandemic potential, as well as for basic research on the influenza A virus.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalExpert Review of Proteomics
Issue number3
Publication statusPublished - 2010 Jun


  • Avian
  • Evolution
  • Host
  • Infectious diseases
  • Influenza
  • Mutation
  • Pandemic
  • Swine
  • Zoonosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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