Abstract
Evaluation of: Miotto O, Heiny AT, Albrecht R et al. Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains. PLoS ONE 5(2), e9025 (2010). The emergence of an influenza pandemic is of great concern globally. It is, therefore, necessary to have a better understanding of the adaptation of influenza A viruses to humans. The mutation patterns affecting host tropism may provide information on the mechanisms and determinants of the host barrier. The work by Miotto et al. describes a catalog of mutations observed specifically in human influenza A viruses by analyzing almost 100,000 influenza A virus protein sequences. These sites may be important for host tropism and characteristic mutations of human influenza viruses may be required for efficient human-to-human transmission. The catalog can be used for genetic surveillance of zoonotic strains of the influenza A virus to determine their pandemic potential, as well as for basic research on the influenza A virus.
Original language | English |
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Pages (from-to) | 323-326 |
Number of pages | 4 |
Journal | Expert Review of Proteomics |
Volume | 7 |
Issue number | 3 |
DOIs |
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Publication status | Published - 2010 Jun |
Keywords
- Avian
- Evolution
- Host
- Infectious diseases
- Influenza
- Mutation
- Pandemic
- Swine
- Zoonosis
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology