Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production

Hiroyuki Tada; Shunji Sugawara; Eiji Nemoto; Nobuhiro Takahashi; Takahisa Imamura; Jan Potempa; James Travis; Hidetoshi Shimauchi; Haruhiko Takada

doi:10.1128/IAI.70.6.3304-3307.2002

Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production

Hiroyuki Tada, Shunji Sugawara, Eiji Nemoto, Nobuhiro Takahashi, Takahisa Imamura, Jan Potempa, James Travis, Hidetoshi Shimauchi, Haruhiko Takada

DEN - Dental Sciences

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.

Original language	English
Pages (from-to)	3304-3307
Number of pages	4
Journal	Infection and immunity
Volume	70
Issue number	6
DOIs	https://doi.org/10.1128/IAI.70.6.3304-3307.2002
Publication status	Published - 2002

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/IAI.70.6.3304-3307.2002

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Tada, H., Sugawara, S., Nemoto, E., Takahashi, N., Imamura, T., Potempa, J., Travis, J., Shimauchi, H., & Takada, H. (2002). Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production. Infection and immunity, 70(6), 3304-3307. https://doi.org/10.1128/IAI.70.6.3304-3307.2002

Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production. / Tada, Hiroyuki ; Sugawara, Shunji ; Nemoto, Eiji et al.

In: Infection and immunity, Vol. 70, No. 6, 2002, p. 3304-3307.

Research output: Contribution to journal › Article › peer-review

Tada, H , Sugawara, S , Nemoto, E , Takahashi, N, Imamura, T, Potempa, J, Travis, J, Shimauchi, H & Takada, H 2002, 'Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production', Infection and immunity, vol. 70, no. 6, pp. 3304-3307. https://doi.org/10.1128/IAI.70.6.3304-3307.2002

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abstract = "Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.",

author = "Hiroyuki Tada and Shunji Sugawara and Eiji Nemoto and Nobuhiro Takahashi and Takahisa Imamura and Jan Potempa and James Travis and Hidetoshi Shimauchi and Haruhiko Takada",

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AU - Tada, Hiroyuki

AU - Sugawara, Shunji

AU - Nemoto, Eiji

AU - Takahashi, Nobuhiro

AU - Imamura, Takahisa

AU - Potempa, Jan

AU - Travis, James

AU - Shimauchi, Hidetoshi

AU - Takada, Haruhiko

PY - 2002

Y1 - 2002

N2 - Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.

AB - Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.

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Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production

Abstract

ASJC Scopus subject areas

UN SDGs

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