TY - JOUR
T1 - Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production
AU - Tada, Hiroyuki
AU - Sugawara, Shunji
AU - Nemoto, Eiji
AU - Takahashi, Nobuhiro
AU - Imamura, Takahisa
AU - Potempa, Jan
AU - Travis, James
AU - Shimauchi, Hidetoshi
AU - Takada, Haruhiko
PY - 2002
Y1 - 2002
N2 - Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.
AB - Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.
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U2 - 10.1128/IAI.70.6.3304-3307.2002
DO - 10.1128/IAI.70.6.3304-3307.2002
M3 - Article
C2 - 12011031
AN - SCOPUS:0036259850
VL - 70
SP - 3304
EP - 3307
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 6
ER -