Protein subcellular localization prediction with WoLF PSORT

Paul Hortona; Keun Joon Park; Takeshi Obayashi; Kenta Nakai

Protein subcellular localization prediction with WoLF PSORT

Paul Hortona, Keun Joon Park, Takeshi Obayashi, Kenta Nakai

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present a new program for predicting protein subcellular localization from amino acid sequence. WoLF PSORT is a major update to the PSORTII program, based on new sequence data and incorporating new features with a feature selection procedure. Following SWISS-PROT, we divided eukaryotes into three groups: fungi, plant, and animal. For the 2113 fungi proteins divided into 14 categories; we found that, combined with BLAST, WoLF PSORT yields a cross-validated accuracy of 83%, eliminating about1/3 of the errors made when using BLAST alone. For 12771 animal proteins a combined accuracy of 95.6% is obtained, eliminating 1/4 of BLAST alone errors, and for 2333 plant proteins the accuracy can be improved to 86% from 84%.

Original language	English
Title of host publication	Proceedings of the 4th Asia-Pacific Bioinformatics Conference, APBC 2006
Pages	39-48
Number of pages	10
Publication status	Published - 2006 Dec 1
Externally published	Yes
Event	4th Asia-Pacific Bioinformatics Conference, APBC 2006 - Taipei, Taiwan, Province of China Duration: 2006 Feb 13 → 2006 Feb 16

Publication series

Name	Series on Advances in Bioinformatics and Computational Biology
Volume	3
ISSN (Print)	1751-6404

Other

Other	4th Asia-Pacific Bioinformatics Conference, APBC 2006
Country/Territory	Taiwan, Province of China
City	Taipei
Period	06/2/13 → 06/2/16

ASJC Scopus subject areas

Bioengineering
Information Systems

Cite this

Protein subcellular localization prediction with WoLF PSORT. / Hortona, Paul; Park, Keun Joon; Obayashi, Takeshi et al.

Proceedings of the 4th Asia-Pacific Bioinformatics Conference, APBC 2006. 2006. p. 39-48 (Series on Advances in Bioinformatics and Computational Biology; Vol. 3).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hortona, P, Park, KJ, Obayashi, T & Nakai, K 2006, Protein subcellular localization prediction with WoLF PSORT. in Proceedings of the 4th Asia-Pacific Bioinformatics Conference, APBC 2006. Series on Advances in Bioinformatics and Computational Biology, vol. 3, pp. 39-48, 4th Asia-Pacific Bioinformatics Conference, APBC 2006, Taipei, Taiwan, Province of China, 06/2/13.

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Protein subcellular localization prediction with WoLF PSORT

Abstract

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ASJC Scopus subject areas

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