Protein stabilization by an amphiphilic short monodisperse oligo(ethylene glycol)

Nabanita Sadhukhan, Takahiro Muraoka, Mihoko Ui, Satoru Nagatoishi, Kouhei Tsumoto, Kazushi Kinbara

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A short, monodisperse additive (octa(ethylene glycol) monophenyl ether) functions to suppress aggregation of thermally and chemically denatured lysozyme. Control studies with shorter and non-amphiphilic derivatives revealed that the amphiphilic structure is essential, and octa(ethylene glycol) is nearly the minimum chain length for amphiphilic poly(ethylene glycol)s to stabilize proteins. This journal is

Original languageEnglish
Pages (from-to)8457-8460
Number of pages4
JournalChemical Communications
Volume51
Issue number40
DOIs
Publication statusPublished - 2015 May 18

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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