Protein-losing gastroenteropathy with severe hypoalbuminemia associated with Sjögren’s syndrome: A case report and review of the literature

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Abstract

A 30-year-old man with severe hypoalbuminemia (serum albumin: 0.9 g/dL) was admitted with severe bilateral leg edema and unilateral pleural effusion. Serum anti-SS-A and SS-B antibody levels were abnormally elevated, and his symptoms fulfilled the diagnostic criteria for Sjögren's syndrome. Technetium-99m albumin scintigraphy revealed protein leakage from a large area of the small intestine. Immunohistochemistry revealed perivascular deposition of C1q, C3d, and immunoglobulin G in the duodenal mucosa. The patient was diagnosed with protein-losing gastroenteropathy associated with Sjögren's syndrome. Within 2 months of treatment with oral prednisolone and mycophenolate mofetil, the clinical symptoms of hypoalbuminemia and Sjögren's syndrome disappeared completely.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalJournal of General and Family Medicine
Volume21
Issue number1
DOIs
Publication statusPublished - 2020 Jan

Keywords

  • Sjögren's syndrome
  • human serum albumin scintigraphy
  • hypoalbuminemia
  • protein-losing gastroenteropathy

ASJC Scopus subject areas

  • Family Practice
  • Geriatrics and Gerontology
  • Internal Medicine

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