Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases

Byung Ha Chung, Sun Woo Lim, Kyung Ohk Ahn, Akira Sugawara, Sadayoshi Ito, Bum Soon Choi, Yong Soo Kim, Byung Kee Bang, Chul Woo Yang

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Peroxisome proliferator activated receptor gamma (PPARγ) agonist has not only antidiabetic effect but also a protective effect against various types of injury of the kidney. The protective effects of PPARγ agonists are observed in diabetic nephropathy and non-diabetic renal diseases such as 5/6 ablation model of renal failure, experimental glomerulonephritis, ischemia-reperfusion injury, hypertensive nephropathy and cyclosporin-induced renal injury. The mechanism of renoprotection by PPARγ agonist is multifactorial. Anti-fibrotic and anti-inflammatory effects, suppression of renin-angiotensin system, vascular protective effect and antiapoptotic effect were proposed.

Original languageEnglish
Pages (from-to)S40-S43
JournalNephrology
Volume10
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2005 Oct

Keywords

  • Diabetic nephropathy
  • Kidney disease
  • Peroxisome proliferator activated receptor-gamma
  • Rosiglitazone

ASJC Scopus subject areas

  • Nephrology

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