Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice

Naganuma Akira, Satoh Masahiko, Koyama Yuko, Imura Nobumasa

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

A protective effect of preadministration of the metals Cu, Bi, Zn, Hg, Cd, Ni or Co, against lethal toxicity of cis-diamminedichloroplatmum (Cisplatin; CDDP) was observed in mice. However, the protective effect seems not always to correlate with metallothionein (MT) levels in the liver and kidney of mice treated with one of these metals, suggesting possible participation in this protection of mechanisms other than MT induction by the preadministered metals.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalToxicology Letters
Volume24
Issue number2-3
DOIs
Publication statusPublished - 1985 Jan 1

Keywords

  • (cis-Diamminedichloroplatinum
  • metal effect
  • metallothionein)
  • toxicity

ASJC Scopus subject areas

  • Toxicology

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