TY - JOUR
T1 - Protective effect of melatonin on methylmercury-induced mortality in mice
AU - Kim, Choong Yong
AU - Nakai, Kunihiko
AU - Kameo, Satomi
AU - Kurokawa, Naoyuki
AU - Liu, Zhang Min
AU - Satoh, Hiroshi
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2000/8
Y1 - 2000/8
N2 - Effect of melatonin on the mortality in methylmercury chloride (MMC)-intoxicated mice was evaluated. Mice were given MMC in the diet (40 mgHg/g) with or without melatonin in drinking water (20 mg/ml) for 5 weeks. In the control group, given MMC alone, 4 of 10 mice began to show neurological signs (e.g., abnormal righting reflex, staggering gaitfallen and posture on its side) concomitant with loss of body weight 4-7 days before death. This group also showed 60% of survival rate on the 35th day. However, the treated group, concomitantly given melatonin, showed a 100% of survival rate on the 35th day, although 1 of 10 mice began to show the neurological signs on the 33rd day. The level of thiobarbituric acid reactive substance in the brain, as an indication of oxidative damage, showed a significant u decrease in the treated group compared with the control group. Thus, the 100% survival rate in the treated group may be partly due to antioxidative effect of melatonin on the MMC induced neurotoxicity. (C) 2000 Tohoku University Medical Press.
AB - Effect of melatonin on the mortality in methylmercury chloride (MMC)-intoxicated mice was evaluated. Mice were given MMC in the diet (40 mgHg/g) with or without melatonin in drinking water (20 mg/ml) for 5 weeks. In the control group, given MMC alone, 4 of 10 mice began to show neurological signs (e.g., abnormal righting reflex, staggering gaitfallen and posture on its side) concomitant with loss of body weight 4-7 days before death. This group also showed 60% of survival rate on the 35th day. However, the treated group, concomitantly given melatonin, showed a 100% of survival rate on the 35th day, although 1 of 10 mice began to show the neurological signs on the 33rd day. The level of thiobarbituric acid reactive substance in the brain, as an indication of oxidative damage, showed a significant u decrease in the treated group compared with the control group. Thus, the 100% survival rate in the treated group may be partly due to antioxidative effect of melatonin on the MMC induced neurotoxicity. (C) 2000 Tohoku University Medical Press.
KW - Intoxication
KW - Melatonin
KW - Methylmercury
KW - Neurotoxicity
KW - Survival rate
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U2 - 10.1620/tjem.191.241
DO - 10.1620/tjem.191.241
M3 - Article
C2 - 11038016
AN - SCOPUS:0033637177
VL - 191
SP - 241
EP - 246
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 4
ER -