Protective effect of Japanese green tea extract on gnotobiotic mice infected with an Escherichia coli O157:H7 strain

Emiko Isogai, Hiroshi Isogai, Koichi Takeshi, Takeshi Nishikawa

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    We examined the effect of Japanese green tea extract (JGTE) on enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection in a gnotobiotic mouse model. Gnotobiotic mice inoculated with an EHEC strain developed neurologic and systemic symptoms, usually culminating in death. In contrast, none of mice receiving dietary JGTE showed clinical signs or death. This report describes the effect of JGTE, which includes the inhibition of bacterial growth in vivo. The Shiga-like toxin (SLT) level in the feces of the JGTE diet group was significantly lower than that of the control group.

    Original languageEnglish
    Pages (from-to)125-128
    Number of pages4
    JournalMICROBIOLOGY and IMMUNOLOGY
    Volume42
    Issue number2
    DOIs
    Publication statusPublished - 1998 Jan 1

    Keywords

    • Escherichia coil O157
    • Gnotobiotic mouse
    • Japanese green tea

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Virology

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