Protective effect of carnosine on febrile seizures in immature mice

Yun Jian Dai, Deng Chang Wu, Bo Feng, Wei wei Hou, Ceng Lin Xu, Hiroshi Ohtsu, Zhong Chen, Wei Wei Hu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Febrile seizures (FSs) are the most common type of convulsions in childhood and complex FSs represent an increased risk for development of temporal lobe epilepsy. The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice. Injection of carnosine significantly increased the latency and decreased the duration of FSs in a dose-dependent manner. In addition, histidine had similar effects on FSs as carnosine. The protective effect of carnosine or histidine was completely abolished by α-fluoromethylhistidine (α-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice. Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus. These results indicate that carnosine can protect against FSs in mice pups through its conversion to histamine, suggesting that it may serve as an efficient anti-FSs drug in the future.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalNeuroscience Letters
Volume588
DOIs
Publication statusPublished - 2015 Feb 19

Keywords

  • Carnosine
  • Febrile seizure
  • Glutamate
  • Histamine
  • Histidine

ASJC Scopus subject areas

  • Neuroscience(all)

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