Protective effect of captopril and enaraprilat, angiotensin-converting enzyme inhibitors, on para-nonylphenol-induced {radical dot}OH generation and dopamine efflux in rat striatum

Toshio Obata, Shigehiro Takahashi, Yoshitomo Kashiwagi, Shunichiro Kubota

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

We recently reported that para-nonylphenol, an environmental chemical, induced hydroxyl radical ({radical dot}OH) formation in rat striatum. In this study we examined the antioxidant effects of angiotensin-converting enzyme inhibitors (captopril or enalaprilat) on para-nonylphenol (nonylphenol) and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical ({radical dot}OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum, using a microdialysis technique. para-Nonylphenol clearly enhanced {radical dot}OH formation and DA efflux induced by MPP+. When captopril or enalaprilat was infused in nonylphenol and MPP+-treated rats, DA efflux and {radical dot}OH formation significantly decreased, as compared with that in the nonylphenol and MPP+-treated control. We compared the ability of non-SH-containing enalaprilat with a SH-containing captopril to scavenge {radical dot}OH and DA efflux. Both inhibitors were able to scavenge {radical dot}OH and DA efflux induced by para-nonylphenol and MPP+. The results suggest that angiotensin-converting enzyme inhibitors may protect against nonylphenol and MPP+-induced {radical dot}OH formation via suppressing DA efflux in the rat striatum.

Original languageEnglish
Pages (from-to)96-99
Number of pages4
JournalToxicology
Volume250
Issue number2-3
DOIs
Publication statusPublished - 2008 Sep 4

Keywords

  • 1-Methyl-4-phenylpyridinium ion (MPP)
  • Angiotensin-converting enzyme inhibitor
  • Dopamine
  • Hydroxyl radical
  • Striatum
  • para-Nonylphenol

ASJC Scopus subject areas

  • Toxicology

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