Protection against the diabetogenic effect of feeding tert-butylhydroquinone to rats prior to the administration of streptozotocin

Shoko Nishizono, Tadao Hayami, Ikuo Ikeda, Katsumi Imaizumi

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

We determined whether an oral administration of the synthetic antioxidant, tert-butylhydroquinone (TBHQ), or the naturally occurring lipoxygenase inhibitor, curcumin, to rats would provide protection against the diabetogenic effect of streptozotocin (STZ). Male Sprague-Dawley rats were fed on an AIN-76™-based purified diet containing 0.0028% TBHQ or on the purified diet with a daily intragastric administration of curcumin (200 mg/kg of body weight) for one week while receiving intravenously administered STZ. The rats fed on the TBHQ-containing diet were resistant to diabetes development when compared with the rats fed on the TBHQ-free diet and had a higher body weight gain and lower serum glucose concentration. Glucose-stimulated insulin secretion from the pancreatic islet in the rats that had received TBHQ was higher than that in the control rats. The rats receiving curcumin showed no beneficial effect on these diabetic symptoms. These findings provide direct evidence for the suggestion that dietary supplementation of an antioxidant may exert a preventive effect on the diabetogenic action of free-radical producers.

Original languageEnglish
Pages (from-to)1153-1158
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume64
Issue number6
DOIs
Publication statusPublished - 2000 Jan 1
Externally publishedYes

Keywords

  • Curcumin
  • Diabetes
  • Insulin release
  • Pancreatic islet
  • Tert-butylhydroquinone

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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