Protection against lethal toxicity of various anticancer drugs by preinduction of metallothionein synthesis in mice

M. Satoh, T. Tsuchiya, Y. Kumada, A. Naganuma, N. Imura

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The effect of pretreatment with metallothionein (MT) inducing metal compounds (bismuth subnitrate (BSN) or ZnCl2) on survival rates of mice receiving various anticancer drugs was investigated. The survival rates of BSN-pretreated mice were 100, 63, 43, and 100% in cis-diamminedichloroplatinum, adriamycin, peplomycin, and 5-fluorouracil treated groups, respectively, although mice given an anticancer drug alone died within 13 days. Moreover, pretreatment with ZnCl2 remarkably reduced lethality of cyclophosphamide in addition to that of the other drugs described above. These results suggest that MT inducing agents may be effective as protective agents against certain side effects of various anticancer drugs

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalJournal of Trace Elements in Experimental Medicine
Volume6
Issue number1
Publication statusPublished - 1993 Jan 1

Keywords

  • 5-fluorouracil
  • Adriamycin
  • Bi
  • Cis-diamminedichloroplatinum
  • Cyclophosphami de
  • Zn

ASJC Scopus subject areas

  • Biochemistry

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