Abstract
'Rhaz'zmatazz: A total synthesis of (-)-rhazinilam and the first asymmetric total synthesis of (-)-rhazinicine were accomplished by using constructing the indolizinone core through the gold-catalyzed cyclization of a fully elaborated linear ynamide. The scope and generality of this cascade reaction for the construction of highly substituted indolizinones were also investigated.
Original language | English |
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Pages (from-to) | 7168-7171 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 28 |
DOIs | |
Publication status | Published - 2013 Jul 8 |
Keywords
- alkaloids
- cyclization
- gold
- natural products
- total synthesis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)