Prostate-specific antigen adjusted for total prostatic tumor volume as a predictor for outcome after radical prostatectomy

N. Hayashi, M. Urashima, I. Ikemoto, H. Kuruma, Y. Arai, S. Kuwao, S. Baba, S. Egawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this study was to investigate the potential prognostic value of preoperative serum prostate-specific antigen levels adjusted for total tumor volume (PSA-TTV density) for outcome following radical prostatectomy for prostate cancer by retrospective review in 268 patients. Lower PSA-TTV density was not only associated with a significantly higher risk for biological failure (bF), systemic failure and cancer death but also an independent predictor for bF (hazard ratio, 6.3). Therefore, these data suggest that there are subsets of prostate cancer with lower PSA secretion levels, and this phenotype is associated with a higher risk of failure after surgery.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Volume10
Issue number1
DOIs
Publication statusPublished - 2007 Mar

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Fingerprint Dive into the research topics of 'Prostate-specific antigen adjusted for total prostatic tumor volume as a predictor for outcome after radical prostatectomy'. Together they form a unique fingerprint.

  • Cite this