Prostanoids, Coronary Circulation and Coronary Artery Spasm in Open Chest Dogs and Miniature Pigs

Kensuke Egashira, Hiroaki Shimokawa, Hitonobu Tomoike, Motoomi Nakamura

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Effects of prostanoids on coronary circulation were studied in anesthetized open chest dogs with intact coronary arteries or in closed chest Gottingen miniature pigs with denuded vessels. In the latter model, coronary artery spasm was repeatedly provoked at the previously denuded area by histamine i.c. after pretreatment with cimetidine i.v. H2-blocker. In the canine model, prostacyclin (PGI2) dilated to a greater extent the diameter of the large epicardial coronary artery than did PGE2, and both equally reduced the total coronary resistance. Vasoconstrictive effects of carbocyclic thromboxane A2, a stable analogue of thromboxane A2 (TxA2) on the epicardial coronary artery was augmented from 1.1±0.3 to 6.5±1.3% (p<0.01) after pretreatment with cyclooxygenase inhibitors. In case of Göttingen miniature pigs 3 months after endothelial denudation and cholesterol freeding, neither PGI2 nor indomethacin prevented histamine-induced coronary artery spasm. Thiothromboxane A2, a stable analogue of TxA2, did not provoke coronary artery spasm in the animals. Therefore, prostanoids may not be crucial to the provocation or prevention of coronary artery spasm from which myocardial ischemia ensues.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalJAPANESE CIRCULATION JOURNAL
Volume51
Issue number4
DOIs
Publication statusPublished - 1987

Keywords

  • Carbocyclic thromboxane A
  • Indomethacin
  • PGE
  • PGI
  • Thiothromboxane A

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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