Prostacyclin production in cultured endothelial cells is highly sensitive to low doses of ionizing radiation

Y. Hosoi, M. Yamamoto, T. Ono, K. Sakamoto

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

In an attempt to detect if low doses of ionizing radiation affect the physiological function of blood vessels, the effect of prostacyclin production was examined using cultured endothelial cells. Irradiation with 5 cGy suppressed the production to 53% of the levels in unirradiated control cells. The PGI2 production decreased with an increase in the dose, showing a maximal decrease at 100 cGy without further decrease at 200 cGy. The suppressive effect lasted for 15 min after irradiation and disappeared later. Preincubation with αtocopherol abrogated the suppressive effect completely, although preincubation with ascorbic acid showed little effect. These results suggest that low dose irradiation inhibits the prostacyclin production by changing the cellular membranes transiently.

Original languageEnglish
Pages (from-to)631-638
Number of pages8
JournalInternational Journal of Radiation Biology
Volume63
Issue number5
DOIs
Publication statusPublished - 1993 Jan 1

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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